Doctors would be able to test for resistance to widely used tamoxifen
WASHINGTON - Scientists have pinpointed the molecular on-off switch that the powerful drug tamoxifen uses to attack breast cancer and which prevents it from working in some women.
That discovery should eventually help doctors test for resistance to the drug, the chief treatment for breast cancers that are estrogen-driven, researchers said. Tamoxifen doesn't work in about one-quarter to one-third of women who are treated with it.
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